Belle and Sebastian is an anime adaption of a series of French novels called Belle et Sébastien by Cécile Aubry. The series ran on the Japanese network NHK from April 7, 1981 – June 22, 1982. It consists of 52 episodes and was a co-production of MK Company, Visual 80 Productions and Toho Company, Ltd.. Toshiyuki Kashiwakura was the head writer and character designs were by Shuichi Seki. The show was broadcast on French and Japanese television in 1981, with American cable network Nickelodeon picking it up in 1984. In the United Kingdom, it aired on Children's BBC in 1989 and 1990. This anime used many staffers from Nippon Animation's World Masterpiece Theater franchise, thus the look and feel is similar to that of a WMT production even though Nippon Animation itself was not involved with this series. The series has been aired in many countries outside Japan and has been dubbed and subtitled in English and numerous other languages.

With no witnesses, no traces, and no corpse, Josy, the 13-year-old daughter of well-known psychiatrist Viktor Larenz, has disappeared in unexplained circumstances. Two years later, a mysterious woman appears. She forces Viktor to face up to his daughter's disappearance and pushes him to his psychological limits.

When Sebastian, a young orphan living in the Alps, meets Belle, a huge white Great Pyrenees, they set off together on a series of fantastic adventures around the mountains.

Leon Alastray is an outlaw who has been given sanctuary by Father John, whom he then escorts to the village of San Sebastian. The village is deserted, with its cowardly residents hiding in the hills from Indians, who regularly attack the village and steal all their supplies. When Father John is murdered, the villagers mistakenly think the outlaw is the priest. Alastray at first tells them he is not a priest, but they don't believe it, and an apparent miracle seems to prove they are correct. Eventually, he assists them in regaining their confidence and defending themselves.

Belle and Sebastian is set high in the snowy Alps during the Second World War. The resourceful Sebastian is a lonely boy who tames and befriends a giant, wild mountain dog, Belle – even though the villagers believe her to be ‘the beast’ that has been killing their sheep.

September, 1945. Sebastian impatiently waits for the return of his friend Angelina, whom he has not seen for two years. When the plane carrying the young woman to her small village in the Alps is reported to have crashed in the mountains, Sebastian is convinced that Angelina is still alive. Along with his faithful dog Belle, Sebastian embarks on the most dangerous adventure of his life.